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Lower pools of reduced glutathione have been associated with the severity of the autoimmune response, cell apoptosis (death), and autoantibody production

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The histidine imidazole nitrogen, the glycine -amino group, and the glycine carbonyl oxygen coordinate to the Cu ion in a square-planar geometry, creating a stable chelate with a dissociation constant in the femtomolar range

Historically, most peptides have been considered ineffective when swallowed because digestive enzymes in the stomach and small intestine break down protein structures before they can be absorbed

GLUTATHIONE IN ENDOPLASMIC RETICULUM In ER, glutathione exists mainly as oxidized glutathione (GSSG)