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Remarkably, studies show that GLP-1s affect specific brain regions involved in appetite control, decreasing neuronal responses to food images and reducing cravings for high-fat foods

Diet matters: The Mediterranean dietary pattern has been consistently associated with better semen parameters

BMI of 25 or higher

These fundamentals are important for pelvic health at any time not just after significant weight loss

Light exposure deserves careful attention

Other risk factors that may increase vulnerability include: Long duration of diabetes (typically more than 10 years) Poor glycaemic control prior to starting GLP-1 therapy (HbA1c significantly above target) Rapid reduction in HbA1c (a drop of more than 2 percentage points [22 mmol/mol] within 36 months) Concurrent hypertension , especially if poorly controlled Diabetic kidney disease (nephropathy), which often correlates with retinopathy severity Previous history of retinal treatment (laser photocoagulation or intravitreal injections) People with type 2 diabetes but no retinopathy appear to have minimal risk of retinopathy progression based on current evidence