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Some patients also anecdotally report dry mouth while taking tirzepatide, though this is not prominently featured in clinical trial data
In a review of studies involving 1604 individuals with metabolic syndromes and related disorders, curcumin intake significantly reduced BMI, weight and waist-circumference (2)(3)
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Biomarkers like fasting insulin, HOMA-IR, C-peptide, and lipid profiles provide real-time context about insulin resistance and metabolic function
Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate
doi:10.1111/j.1464-410X.2012.11577.x
