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The mean age of the 201,459 study subjects was 53.2 years

Nrf2 plays a central role in cellular defense against oxidative insults, tightly regulating the activation of specific downstream targets, including glutathione and thioredoxin systems, detoxification system, NADPH regeneration, and heme and iron metabolism (20)

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From the above findings, it was presumed that the anti-inflammatory action of the Si-based agent was mediated by two mechanisms: a direct anti-inflammatory action via the generated hydrogen and an indirect anti-inflammatory action through the induced RSS

P., Jr (2018)