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Therefore, the inducing factors and specific mechanisms of ferroptosis in AD remain to be elucidated and should be the focus of next studies

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PubMed, Chappell, Kenneth, et al

The result is a quadruple agonist approach to metabolic optimization that goes beyond what even the most aggressive single-agent protocols can deliver

The authors show that LXA4 activates the expression of GPX4, lysophosphatidic acid receptor-3 (LPAR3), and estrogen receptor beta (ESR2) in FLSs, which inhibits ferroptosis and reduces inflammation and chondrocyte matrix breakdown

The degradation process of tryptophan in KP produces a variety of neuroactive metabolites with amino acid-like structures, such as an N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid (QA), and a neuroprotective NMDA receptor agonist kynurenic acid (KYNA)