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Its generally considered safe to do so, provided you stay well below the upper limit of 40 mg daily, which can be toxic

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)

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| Concentration | BAC Water | Doses at 0.5mg | Doses at 1.0mg | |---------------|-----------|----------------|----------------| | 5mg/mL (recommended) | 1.0mL | 10 doses | 5 doses | | 2.5mg/mL | 2.0mL | 10 doses | 5 doses | **Best practice:** Use 1.0mL BAC water (5mg/mL)

Its ability to cross the blood-brain barrier allows it to act directly on central nervous system structures involved in sleep regulation and stress response

Efficacy of Plasma Exchange Therapy vs Standard Medical Therapy in Severe Alcoholic Hepatitis With High Discriminant Function