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among individuals with overweight or obesity without diabetes, the combination of 5% weight loss with modest systolic blood pressure reduction suggests potential multidimensional net benefit, provided that tolerability management and discontinuation-risk counseling are undertaken concurrently

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The number of viable cells was measured by flow cytometry after addition of 5 l spike in fluorescently labeled bead (CountBright Plus Absolute Counting Beads, ThermoFisher Scientific) for normalization