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Oral glutathione supplementation is often debated due to its potential effectiveness and absorption challenges, as digestive enzymes may degrade it

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Therefore, incorporating sex-based molecular and comorbidity differences into research and clinical guidelines is essential for developing safer and more personalized medical practices 108

1,2 While some nutrient depletions may be intentional (i.e., cancer treatments depleting folate), others may result in new comorbidities or unintended consequences

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Untreated hypothyroidism blunts response