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Antioxidant supplementation in sepsis and systemic inflammatory response syndrome

Edaravone prevents reactive oxygen species from being formed and/or removes them before they can damage neurons, in effect limiting apopotosis of post synaptic terminals as well as the inactivation of EAAT2 receptors in astrocytes and increasing the rate of glutamate re-uptake (Figure 1)

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The surging demand has made GLP-1 therapies the fastest-growing sector in diabetes/obesity pharmacotherapy

Tirzepatide 15 mg was also associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59], I 2 0%) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85], I 2 52%), while more participants receiving tirzepatide 10 mg experienced vomiting (OR 2.98 [95% CI 1.13, 7.80], I 2 0%) (Table 2)