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10.1080/10408398.2019.1588223 Crit Rev Food Sci Nutr

Hereditary spastic paraplegia is a common phenotypic finding in ARG1 deficiency, P5CS deficiency and HHH syndrome: three inborn errors of metabolism caused by alteration of an interconnected pathway of glutamate and urea cycle metabolism

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Recent reviews have highlighted potential immunomodulatory effects across diverse autoimmune contexts, suggesting that the observed anti-inflammatory properties may extend beyond metabolic improvement (77)