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Or, indeed, semaglutide might have a direct effect on fertility that we don't yet know about

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Standing instead of sitting, taking stairs instead of elevators, walking while on phone calls, doing yard work, and generally staying physically active throughout the day all contribute

Mechanistically, this relationship is driven by chronic low-grade inflammation, insulin resistance, increased levels of insulin and IGF-1, elevated estrogen and adipokines such as leptin, and impaired immune surveillance, all of which contribute to tumor initiation, proliferation, and evasion of apoptosis [144]