Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose
That's changing
For example, many oral versions of peptides (like BPC-157 and Thymosin Beta 4) are not bannedits just the injectables
10.3 Are there any side effects when starting peptide therapy
The solution is straightforward: split the dose into two injections administered at different sites within the same session
I have patients who cannot tolerate Wegovy (semaglutide) but can tolerate Zepbound (tirzepatide), or, alternatively, they tolerate Wegovy but not Zepbound," she says