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Eligibility criteria include specific BMI thresholds, presence of comorbidities such as type 2 diabetes or cardiovascular disease, and previous weight loss attempts

When you're eating less food overall, every bite needs to count

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Why this matters for drug discovery Editor's note: Updated July 27, 2026 with the published evoke and evoke+ biomarker data from The Lancet, including neurofilament light and GFAP results that point in conflicting directions

SURMOUNT-5: Tirzepatide vs Semaglutide for Weight Management

Real-world data from the SUSTAIN trials revealed that semaglutide reduced triglycerides by an average of 1525% across study populations