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Your individual experience depends on genetics, starting dose, eating patterns, and gastrointestinal baseline sensitivity

Recognizing this pattern helps maintain realistic expectations and prevents premature discontinuation of effective therapy

When to Expect Appetite Changes Initial Effects (1-2 Weeks): Semaglutide GLP-1 begins to show effects relatively quickly, but most users notice significant changes in appetite within the first 1 to 2 weeks

Taking doses closer than 48 hours apart may increase gastrointestinal side effects like nausea, vomiting, and diarrhea, and could affect blood glucose control

Feb 1999;22(2):233-240

Together, well assess your past strategies, identify what drives you, and leverage your strengths to achieve your goals