As per Rahimis (83) findings, it has been observed that the endothelium possesses tightly specialized cell-to-cell junctions, which function as a selective barrier to impede the passage of macromolecules
That said, in vivo potency ranking doesnt track directly with Ki values
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As proposed by others, the increase in incidence rate of chronic inflammatory conditions in the ART era, of not just emphysema and COPD but also diabetes and cardiovascular disease, can largely be explained by improved life expectancies in treated PLWH, giving them more time to develop these co-morbidities (163, 164)
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However, its clinical utility is limited due to rapid enzymatic breakdown