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While generally well-tolerated, some people might experience minor side effects, such as abdominal discomfort or allergic reactions

A 2015 research review linked taking too much B12 to acne, rosacea, vitiligo, and atopic dermatitis

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Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR III, Aguilar RB

When administered orally or intravenously, glutathione supplementation raises intracellular GSH levels, which shifts the melanocyte's redox state from oxidising to reducing

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