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An estimated 20% of people (one in five) taking a GLP-1 experience nausea

Side effects, when they occur, are typically mild and may include digestive discomfort or allergic reactions in sensitive individuals

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We conclude that central and peripheral GLP-1 systems suppress eating via independent gutbrain circuits, providing a rationale for pharmacological activation of PPG NTS neurons in combination with GLP-1 receptor agonists as an obesity treatment strategy

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