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Weeks 812: Measurable improvements in skin firmness and the appearance of fine lines

Tirzepatide adds GIP (~20.9%)

As multiple studies now show an impact of APOE on brain bioenergetics, which occurs prior to the onset of significant AD pathologies (Reiman et al., 1996), it is anticipated that improving our understanding of the L-carnitine system will help us better appreciate these early bioenergetics changes that could precede brain amyloid and tau pathologies and as such provide avenues for AD prevention

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Not recommended for children, pregnant or breastfeeding women

The near-term calendar is dense: second-quarter results on 5 August, an orforglipron diabetes filing, further retatrutide readouts, and an investor meeting on 7 December