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With proper protein strategy, participants lost 65 pounds fat and only 3 pounds muscle over 48 weeks
FDA-approved for chronic weight management at doses up to 2.4 mg weekly
Fasting glucose, A1c, complete lipid panel, liver enzymes, basic metabolic panel
Results showed that a twice daily IGF-1 dose of 120mcg/kg produced almost identical effects as that of a twice daily 80mcg/kg dose [18]
The stop-start pattern of running out early, going without for several days, and then resuming creates more dramatic concentration swings than consistent weekly dosing, potentially worsening the very wearing-off effect that prompted the frequency increase in the first place
People who have established fat-adapted metabolism through keto while on semaglutide generally maintain more weight loss after discontinuation than those without a dietary framework
