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Hinchado MD, Quero-Calero CD, Otero E, Glvez I, Ortega E.Synbiotic Supplementation Improves Quality of Life and InmunoneuroendocrineResponse in Patients with Fibromyalgia: Influence of Codiagnosis withChronic Fatigue Syndrome

4 Although some literature states that it may be used as first-line therapy, tramadol lacks FDA approval and is recommended as an alternative to duloxetine, milnacipran, or pregabalin

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[4] Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness

References 1 AlbanisE.FriedmanS