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Geriatr Gerontol Int 10(Suppl 1):S99S106 Al-Majed AA, Sayed-Ahmed MM, Al-Omar FA, Al-Yahya AA, Aleisa AM, Al-Shabanah OA (2006) Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus

Even after weeks of dosing, no clinically meaningful accumulation occurs

Induction of HO-1 causes abnormal accumulation of ROS due to Fe 2+ accumulation, inducing ferroptosis

Inhibition of miR-144-3p, conversely, restored antioxidant defenses (GPX4, GSH), preserved -cell viability, and improved glycemic control in vivo

The imbalance of mitochondrial fusion/fission drives high-glucose-induced vascular injury

It needs to be protected from industry and shareholder greed