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2021;4(3): e1353

The mechanism here is quite complementary: GLP-1 RAs work by reducing appetite, while Metformin decreases glucose production in the liver

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This occurs through the endothelium-dependent process that activates the PI3-K/eNOS/cGMP phosphoinositide 3-kinase pathway ( 5.3 Nutraceuticals actives Polyphenols play a key role in the therapeutic action based on nutraceutical use

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