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Behavioral and electrophysiological comparison of ketamine with dizocilpine in the rat

Untreated endocrine disorders including hypothyroidism and uncontrolled diabetes require correction before initiating either compound

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA (2001) Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats

Heart rate elevation, a theoretical concern with GLP-1 agonists, occurs modestly (24 bpm increase) and does not translate to increased arrhythmias or sudden cardiac events in study populations

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