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Severely under-eating can lead to fatigue, muscle loss, and nutritional deficiencies

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These studies are rarely done with oral dosing (Brevard et al., 2006) because of the invasive nature of a gastric tube or swallowing a liquid administered into the mouth

This makes it easy to follow the prescribed schedule and ensures safe and accurate dosing

Supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Those criteria exist because the trials that earned approval enrolled patients who met them