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The clinical appearance is of small blue macules or papules almost always on the palates of children or young adults (Figure 5) [34] and is characterised histopathologically by spindle-shaped melanin-producing naevomelanocytes arranged in fascicles parallel to the overlying epithelium, deep within the lamina propria [11, 13, 34]

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Gene expression analysis MC4R KO mice showed a significant increase in fatty acid synthesis-related genes, such as FASN and SCD-1 (Fig

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