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Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41

More serious but rare adverse events include pancreatitis, gallbladder events, and hypoglycemia (primarily in patients using insulin simultaneously)

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Gently swirl or roll instead

Week four: left thigh

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