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Simultaneously, GIPR signaling blocks emesis and attenuates other adverse side effects of GLP-1R activation (43)

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For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months