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if given together FBC monitoring should continue during and for at least 2 months after stopping therapy Hepatic Toxicity: Risk increased with alcohol, retinoids & related compounds (acitretin/etretinate/isotretinoin), sulphasalazine, leflunomide, fluconazole, statins, terbinafine and tamoxifen Nephrotoxicity: Increased with nephrotoxic chemotherapy (e.g