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Given the established cardiovascular and kidney benefits of SGLT2is for T2DM patients with CVDs, those at high risk, and those with CKD, along with recent cohort studies demonstrating their ability to enhance survival, reduce cardiovascular events, and preserve graft function in kidney KTRs with DM, we conducted additional analyses incorporating SGLT2is [38,39,40,41,42]

Amino acid transport: The gamma-glutamyl cycle uses glutathione to transport amino acids across cell membranes, a process essential for cellular amino acid uptake [2][3]

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Zheng H, Jiang L, Tsuduki T, Conrad M, Toyokuni S