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The prevalence of overweight and obesity is a public health issue that has severe cost implications to healthcare systems
In: Overweight and obesity management
The 2023 American Heart Association scientific statement on obesity pharmacotherapy noted: "GLP-1 receptor agonists represent a pharmacologic class with demonstrated cardiovascular benefit that extends beyond traditional risk factor modification, including improvements in inflammation, endothelial function, and atherogenic lipid profiles" 12
Gut microbiome-derived metabolite trimethylamine N-oxide induces aortic stiffening and increases systolic blood pressure with aging in mice and humans
GLP-1 receptor agonists stimulate insulin release from the pancreas only when blood glucose is elevated, suppress glucagon (which reduces liver glucose production), and slow gastric emptying to moderate glucose absorption after meals
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