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Specifically, while light chains of IgG2, IgG3, and IgG4 pair to the CH1 domain of their corresponding HCs through a disulfide bridge between cysteine-214 of the light chain and cysteine-127 at the N-terminus of the CH1, the corresponding pairing in IgG1 occurs with cysteine-233 at the C-terminus of CH1 [258]

The CDAHFD promoted significant changes in SAA metabolites, including reduced S-adenosylmethionine (SAM) and hypotaurine levels, and elevated homocysteine and taurine levels in the liver

The authors concluded that the safety profile of AOD9604 was equivalent to the placebo

Phase 3 REDEFINE trials enrolled over 3,400 participants with 68-week follow-up

10.1038/s41401-020-00516-0 84 FarookU

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