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64 A 90-day administration of dexamethasone (DEX) resulted in significant declines in both BMD and BMC, along with substantial increases in serum levels of glucose, insulin, triglycerides, total cholesterol, parathyroid hormone (PTH), osteoprotegerin (OPG), and bone resorption markers including deoxypyridinoline (DPD), N-terminal telopeptide of type I collagen (NTX-1), and TRAP-5b

The SUSTAIN-6 and LEADER trials tracked patients for 37 years with no concerning safety signals, and cardiovascular benefits persist