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Patients with rheumatoid arthritis who carry specific genetic variantssuch as those affecting the GLP1R or metabolic enzymesmay experience differential responses to semaglutide therapy

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If you plan to use the solution immediately, sterile water for injection is an alternative, but the solution should be used within 24 hours

They are, however, less well tolerated than DPP-4 inhibitors, with gastro-intestinal side-effects of nausea, vomiting and diarrhoea being common following initiation (although these diminish over time in most subjects)

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