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Research has indicated that the -KG-consuming protein Tet3 (the primary -KG-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and then into 5-formyl- and 5-carboxy-dC) reroutes mitochondrial GDH, which converts glutamate into -KG in an NAD + -dependent manner, to the nucleus, indicating the onsite production of -KG

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Silver Spring: FDA, 2005

240 The increased level of inflammatory cytokines may be caused by disturbance of the gut microbiota, which may also disrupt the gut barrier