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19,20 With aging, mitochondrial function declines, leading to decreased energy metabolism, increased ROS production, and the accumulation of mtDNA mutations, alongside the deterioration of other mitochondrial functions
It has been shown that the stimulatory effect of GLP-1 on insulin secretion is, to some extent, dependent on PKC, as evidenced by the ability of the PKC activator phorbol 12-myristate 13-acetate to mimic the effects of GLP-1 on electrical activity
178 SuezJ.ZmoraN.SegalE.ElinavE
But none of this happens fast
It helps transport fats through the bloodstream, preventing their accumulation in the liver
They also slow down the emptying of the stomach, so patients feel satisfied longer after eating smaller meals
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