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NHLBI 2011)

Native GHRH(1-44) is rapidly degraded by dipeptidyl peptidase-4 (DPP-4), giving it a plasma half-life of only minutes

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Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness

However, the work was primarily conducted by one group of researchers in Croatia