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FDA guidance for RUO and investigational labeling in the IVD context stresses that RUO labeling is tied to laboratory research positioning and should not be used to imply broader product status [17] [18]

However, another study using 31 P-MRS to measure cardiac PCr/ATP levels as a marker of myocardial energetics [89], demonstrated a 45% increase in cardiac PCr/ATP in diabetic mice treated with a single dose of empaglifozin, correlating with the increase of circulating ketones but not with plasma glucose levels [85]

At $199 per month plus medication costs, its not the cheapest option, and insurance approvals can take weeks

It is primarily investigated for its interaction with melanocortin receptor subtypes in controlled laboratory environments

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Adding a medication that powerfully affects these systems could create unpredictable interactions