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Notably, all COP1 WD40 domains in each layer face upward, while their coiled-coil domains are positioned downward, stacking onto the WD40 domains of the COP1 molecules in the subsequent layer
Acar T, Kamer E, Acar N, Atahan K, Bag H, Haciyanli M, Akgul O
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Detoxification is especially important when it comes to removing heavy metals like mercury, which can linger in brain tissue and contribute to neurological disorders
Known inhibitors of TGRs/TrxRs, which include metal complexes and compounds containing Michael acceptors or oxadiazole oxides 19,23,24 , usually react with Sec and Cys residues and other biogenic nucleophiles irreversibly
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