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To determine whether dysregulated hepatic glutathione homeostasis and TNF can synergistically contribute to hepatocyte death, we performed cell culture studies using both human hepatoma cells and mouse non-transformed hepatocytes

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STAT3 overexpression is a key molecule that drives the progression of hepatocellular carcinoma, and its activation may be critical in initiating oncogenesis

In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost all cellular processes

As glutathione levels decline with age, this balance tips