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Additionally, in muscle tissue, mitochondrial translation and respiratory genes were also induced, and moreover, patients demonstrated a mild clinical improvement
The STEP program trials with semaglutide (a GLP-1-only agonist) and the SURMOUNT trials with tirzepatide (dual GIP/GLP-1 agonist) represent the strongest weight loss efficacy data in the history of pharmacotherapy for obesity
Sikiric et al., 2020b), it may be indeed that it may endogenously maintain gastrointestinal mucosa integrity (Sikiric et al., 1993
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