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At the end of 16 weeks, the animals were fasted overnight and then euthanized by exposure to isoflurane (Webster Veterinary Supply Inc., Devens, MA)
Chem Res Toxicol 10:310317
J Cell Biol 104(3):689696 Madri JA, Pratt BM, Tucker AM (1988) Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix
(B) 8226/S, 8226/S-CR, 8226/S-ATOR05 control cells, as well as control cells from the indicated time points were harvested and the intracellular GSH concentration was determined as described in the Materials and Methods
The 5-FU mouse model was selected because it is rapidly developed, cost-effective, and closely reflects the pathological features observed in human CIM, making it a widely used approach for evaluating therapeutic candidates (Huang et al
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