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NICE guidelines for type 2 diabetes (NG28) recommend reviewing GLP-1 treatment at around 6 months and continuing only if there has been a meaningful reduction in HbA1c (typically at least 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight
Image credits: Mike Marsland / Axelle/Bauer-Griffin These transformations usually result in the person looking slimmer but without the muscle tone and firmness associated with a slower, less drastic approach to weight loss via diet and exercise
This dietary fiber acts as a prebiotic, fostering the growth of beneficial gut bacteria that are crucial for a balanced microbiome
They mimic the GLP-1 hormone released into the gastrointestinal tract during eating by cells lining the intestinal walls
Effects on GLP-1, PYY, and leptin by direct stimulation of terminal ileum and cecum in humans: implications for ileal transposition
In a large study of over 18,000 patients, rates of gastrointestinal side effects were similar between tirzepatide and semaglutide users, with no significant difference between the drugs
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