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In a 2025 review, people who had been taking semaglutide or tirzepatide regained an average of 53 to 64% of the weight they lost during treatment after about a year

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This interaction triggers c-Met phosphorylation and activates downstream signaling cascades including the PI3K/AKT and MAPK/ERK pathways, which are fundamental to neuronal survival, dendritic arborization, and synapse formation

They may have some options for you to explore, including secondary medications, methods for changing up your diet, or even adjusting your dosage of semaglutide