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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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Chemical reprogramming of human somatic cells to pluripotent stem cells

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This may be attributed to the dimeric structure which hinders enzyme access to active sites, showcasing significant resistance to enzymatic degradation 49,55

The liposomal delivery system is designed for max absorption