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However, the relationship with intestinal NE and GLP-1 has not been clarified

That sits alongside kidney function, thyroid history and cardiovascular risk factors as the items the article says providers assess before initiating therapy at all

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Use a non-oral or backup method of contraception for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase

Current standard-of-care therapies provide median survival of only 14-15 months, highlighting the urgent need for novel therapeutic approaches