Semaglutide is also believed to be a poweful medicine for weight management purpose
Based on a previous systematic review and meta-analysis by He et al
Real change isnt just about making products
Appears to enhance weightloss and glucose effects when combined with GLP1, based on dualagonist data (such as tirzepatide). Glucagon receptor activation Increases energy expenditure and promotes fat oxidation when balanced properly with GLP1 and GIP. May help reduce liver fat and visceral (deep abdominal) fat, which are strongly linked to cardiometabolic risk. By combining these three pathways, retatrutide aims to reduce appetite, improve metabolic control, and increase calorie burning more strongly than current single or dualagonist drugs
Additionally, calcium ions can directly influence mitochondria, disrupting their electron transport chain and further enhancing free radical generation
This is me speculating, but I'm more optimistic about this maintenance phase concept and that [with] the advent of these drugs we perhaps dont have to think about this in only one way