Similar to the responses that occur with other exposures, GSH is initially increased to very high levels in the ELF with CS exposure
Biochemistry 45 , 1352813536 (2006)
Previous observations associated PUFA uptake and mucosal AA accumulation with the risk of developing IBD 20,21,37
The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds
Ribeiro RT, Zanatta , Amaral AU et al (2018) Experimental evidence that in vivo intracerebral administration of L-2-Hydroxyglutaric acid to neonatal rats provokes disruption of redox status and histopathological abnormalities in the brain
CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability