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Prospective studies will be needed to determine whether semaglutide truly increases the risk of NAION, and whether certain formulations, doses, or patient groups are particularly vulnerable

While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]

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Studies used reverse-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography high-resolution mass spectrometry (LC-HRMS) to identify and quantify semaglutide degradation products under various stress conditions