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Resmetirom works independently of weight loss and is particularly well-suited for lean patients, who represent 10% to 20% of the MASH population and often lack procedural options due to body mass index requirements

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However, several safety considerations warrant attention

Gill A, Hoogwerf B, Burger J, Bruce S, MacConell L, Yan P, Braun D, Giaconia J, Malone J: Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study

Availability may be limited by local commissioning decisions and supply constraints, and some patients may need private prescription