Strategies aimed at optimizing the benefits of selenium and selenoproteins should be considered for the therapeutic treatment and prevention of arthropathies
Thus, alterations in redox homeostasis may secondarily shape inflammatory signalling and cellular survival rather than reflecting a fixed pro- or anti-inflammatory role of KP metabolites
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*Correspondence: Zhou-Wei Xu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
FIMM Metabolomics facility is acknowledged for cross-check experimental validation of NADMED method measuring NAD + and NADP + concentrations in blood
Second, the trials allow for flexible dose adjustment, including dose reductions and extension of dose-escalation intervals